Selected Research Publications

  • Parag-Sharma K, O'Banion CP, Henry EC, Musicant AM, Cleveland JL, Lawrence DS, Amelio AL. Engineered BRET-Based Biologic Light Sources Enable Spatio-Temporal Control Over Diverse Optogenetic Systems. ACS Synth Biol. 2020 Jan 17;9(1):1-9. doi: 10.1021/acssynbio.9b00277. Epub 2019 Dec 17. PMID: 31834783
  • Wang L, Lee DJ, Han H, Zhao L, Tsukamoto H, Kim YI, Musicant AM, Parag-Sharma K, Hu X, Tseng HC, Chi JT, Wang Z, Amelio AL, Ko CC. Application of bioluminescence resonance energy transfer-based cell tracking approach in bone tissue engineering. J Tissue Eng. 2021 Feb 16;12:2041731421995465. doi: 10.1177/2041731421995465. PMID: 33643604; PMCID: PMC7894599.

  • Tang Y, Parag-Sharma K, Amelio AL, Cao Y. A Bioluminescence Resonance Energy Transfer-Based Approach for Determining Antibody-Receptor Occupancy In Vivo. iScience. 2019;15:439-51. doi: 10.1016/j.isci.2019.05.003. PubMed PMID: 31121469.

  • Sato K, Parag-Sharma K, Terajima M, Musicant AM, Murphy RM, Ramsey MR, Hibi H, Yamauchi M, Amelio AL. Lysyl hydroxylase 2-induced collagen cross-link switching promotes metastasis in head and neck squamous cell carcinomas. Neoplasia. 2021;23(6):594-606. doi:10.1016/j.neo.2021.05.014.

  • Musicant AM, Parag-Sharma K, Gong W, Sengupta M, Chatterjee A, Henry EC, Tsai YH, Hayward MC, Sheth S, Betancourt R, Hackman TG, Padilla RJ, Parker JS, Giudice J, Flaveny CA, Hayes DN, Amelio AL. CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition. Cell Reports. 2021 Feb 23;34(8):108768. doi: 10.1016/j.celrep.2021.108768. PMID: 33626346; PMCID: PMC7955229.

  • Carper, M. B., Troutman, S., Wagner, B. L., Byrd, K. M., Selitsky, S. R., Parag-Sharma, K., Henry, E. C., Li, W., Parker, J. S., Montgomery, S. A., Cleveland, J. L., Williams, S. E., Kissil, J. L., Hayes, D. N., Amelio, A. L. (2019). An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma. Cell Reports. 2019 Nov 5;29(6):1660-1674.e7. doi: 10.1016/j.celrep.2019.10.005. PMID: 31693903

  • Parag-Sharma K, Tasoulas J, Musicant AM, do Nascimento-Filho CHV, Zhu Z, Twomey C, Liu P, Castilho RM, Amelio AL. Synergistic efficacy of combined EGFR and HDAC inhibitors overcomes tolerance to EGFR monotherapy in salivary mucoepidermoid carcinoma. Oral Oncol. 2021 Apr;115:105166. doi: 10.1016/j.oraloncology.2020.105166. Epub 2021 Feb 11. PMID: 33581505; PMCID: PMC8026571.

  • Tasoulas J, Divaris K, Theocharis S, Farquhar D, Shen C, Hackman T, Amelio AL. Impact of Tumor Site and Adjuvant Radiotherapy on Survival of Patients with Adenoid Cystic Carcinoma: A SEER Database Analysis. Cancers (Basel). 2021 Feb 3;13(4):589. doi: 10.3390/cancers13040589. PMID: 33546179; PMCID: PMC7913220.

  • Uzawa K, Amelio AL, Kasamatsu A, Saito T, Kita A, Fukamachi M, Sawai Y, Toeda Y, Eizuka K, Hayashi F, Kato-Kase I, Sunohara M, Iyoda M, Koike K, Nakashima D, Ogawara K, Endo-Sakamoto Y, Shiiba M, Takiguchi Y, Yamauchi M, Tanzawa H. Resveratrol Targets Urokinase-Type Plasminogen Activator Receptor Expression to Overcome Cetuximab-Resistance in Oral Squamous Cell Carcinoma. Sci Reports. 2019;9(1):12179-13. doi: 10.1038/s41598-019-48717-w. PubMed PMID: 31434965; PMCID: PMC6704133.

  • Amelio AL, Fallahi M, Schaub FX, Zhang M, Zhang M, Lawani MB, Lawani MB, Alperstein AS, Alperstein AS, Southern MR, Southern MR, Young BM, Young BM, Wu L, Zajac-Kaye M, Kaye FJ, Cleveland JL, Conkright MD. CRTC1/MAML2 gain-of-function interactions with MYC create a gene signature predictive of cancers with CREB-MYC involvement. Proc Natl Acad Sci U SA. 2014:201319176. doi: 10.1073/pnas.1319176111. PubMed PMID: 25071166; PMCID: PMC4136562.

  • Saito, T., K. Uzawa, M. Terajima, M. Shiiba, A.L. Amelio, H. Tanzawa, and M. Yamauchi, Aberrant Collagen Cross-linking in Human Oral Squamous Cell Carcinoma. J. Dent. Res. 2019. p. 002203451982871. PubMed PMID: 30786814.

  • Schaub FX, Reza MS, Flaveny CA, Li W, Musicant AM, Hoxha S, Guo M, Cleveland JL, Amelio AL. Fluorophore-NanoLuc BRET Reporters Enable Sensitive In Vivo Optical Imaging and Flow Cytometry for Monitoring Tumorigenesis. Cancer Res. 2015:1-37. doi: 10.1158/0008-5472.CAN-14-3538. PubMed PMID: 26424696.

  • Tasoulas, J., L. Rodón, F.J. Kaye, M. Montminy, and A.L. Amelio, Adaptive Transcriptional Responses by CRTC Coactivators in Cancer. Trends Cancer. 2019. p. 111-127. PubMed PMID: 30755304.

  • Amelio AL, Caputi M, Conkright MD. Bipartite functions of the CREB co-activators selectively direct alternative splicing or transcriptional activation. EMBO J. 2009;28(18):2733-47. doi: 10.1038/emboj.2009.216. PubMed PMID: 19644446; PMCID: PMC2750025.

  • Amelio AL, Miraglia LJ, Conkright JJ, Mercer BA, Batalov S, Cavett V, Orth AP, Busby J, Hogenesch JB, Conkright MD. A coactivator trap identifies NONO (p54nrb) as a component of the cAMP-signaling pathway. Proc Natl Acad Sci U SA. 2007;104(51):20314-9. doi: 10.1073/pnas.0707999105.

  • Cao C, Gao R, Zhang M, Amelio AL, Fallahi M, Chen Z, Gu Y, Hu C, Welsh EA, Engel BE, Haura EB, Cress WD, Wu L, Zajac-Kaye M, Kaye FJ. Role of LKB1-CRTC1 on Glycosylated COX-2 and Response to COX-2 Inhibition in Lung Cancer. J Natl Cancer Inst. 2015;107(1):dju358-dju. doi: 10.1093/jnci/dju358. PubMed PMID: 25465874; PMCID: PMC4271078.