Amelio Lab publishes study demonstrating that biologic light engineered using luminescent-fluorescent protein fusions (LumiFluor) can be spectrally tuned to activate optogenetic tools at spatially illuminated subcellular compartments with dynamic temporal control.
Amelio Lab publishes study describing a new mouse model based on genetic insights gleaned from head and neck cancers linked to human papillomavirus and found that a specific mutation in the gene PIK3CA is key in this cancer type.
Tony Amelio invited to present in the Cancer Models Session at the Salk Institute Mechanisms and Models of Cancer Meeting. The presentation was titled "Illuminating Tumor Biology Using Next Gen Optical Reporter Mouse Models".
Amelio Lab publishes study demonstrating that many patients with oral lesions known as verruciform xanthoma share the same genetic mutations with subjects that have a rare genetic disorder called congenital hemidysplasia with ichthyosiform erythroderma with limb defects (CHILD) Syndrome.
Amelio and colleagues discovered that expression of the gene uPAR mediates acquired resistance to the anti-cancer drug cetuximab in oral squamous cell carcinoma. They also showed that combination therapy with the natural product resveratrol may help overcome this resistance.
The IADR Joseph Lister Award for New Investigators is supported by Johnson & Johnson Consumer Inc., makers of Listerine, and was created to award young investigators with original research in oral disease prevention or oral health promotion.
Ryan Murphy awarded an NRSA F31 fellowship from the National Institute of Dental and Craniofacial Research. Ryan’s project is titled, “Investigating the role of NRF2 in promoting radioresistance in oral squamous cell carcinoma."
Tony Amelio invited to present research from the lab titled "Autochthonous Immunocompetent Models of HPV16-Mediated Oral Tumorigenesis" at the 97th General Session of the International Association for Dental Research held in Vancouver, British Columbia.
Amelio among four teams selected for this year's Translational Team Science (TTS) Award aimed at fostering new synergistic interdisciplinary teams of basic science and clinical investigators.
The American Association for Cancer Research and American Head and Neck Society awarded Siddharth Sheth, a medical oncology fellow mentored by Tony Amelio, a Scholar-in-Training Award at the AACR-AHNS Head and Neck Cancer Conference held in Austin, Texas.
Tony Amelio invited to the 6th Annual Brigham and Women’s Hospital Dermatology Invited Speaker Series to present research from the lab titled "Novel Mouse Models and CRTCal Cell Signaling in HPV16(+) HNSCC"
Amelio Lab co-authors study published in iScience that developed a technology to directly visualize when and where Cetuximab, a therapeutic monoclonal antibody, interacts with its receptor target in the body, in real-time.
Tony Amelio invited to present in the Session on Current Concepts in Salivary Cancer at the Gordon Research Conference on Salivary Glands and Exocrine Biology. The presentation was titled "Mucoepidermoid Carcinoma: CRTCal Links Between CREB and MYC Signaling".
Researchers publish review in Trends in Cancer exploring the role of a group of cellular signaling integrators called cAMP-regulated transcriptional co-activators (CRTCs) in cancer.
Tony Amelio presented a lecture titled "Engineering and Repurposing Biologic Light: Advances in Bioluminescent-Fluorescent BRET Reporters for Optical Imaging" at The Carolina Cancer Nanotechnology Training Program (CCNTP) annual workshop on Cancer Imaging and Non-Invasive Monitoring of Treatment Responses.
Tony Amelio invited to present research from the lab titled "Targeting CREB-MYC Pathway Convergence in Salivary Mucoepidermoid Carcinoma" to the Department of Pharmacology and Physiology at Saint Louis University
Tony Amelio invited to present research from the lab titled "Targeting CREB-MYC Pathway Convergence in Salivary Mucoepidermoid Carcinoma" at the 47th Annual Meeting of the American Association for Dental Research
Adele Musicant awarded an NRSA F31 fellowship from the National Institute of Dental and Craniofacial Research. Adele’s project is titled, “The Role of CRTC1/MAML2-Mediated Interactions with CREB and MYC in Defining the Cellular Heterogeneity of Salivary Tumors."
UNC Lineberger researcher Tony Amelio and his team describe the design and engineering of the new bioluminescent imaging tool called the “LumiFluor” in a study published in the journal Cancer Research.
Antonio Amelio leads study that discovers links between a set of genes known to promote mucoepidermoid carcinoma, an oral cancer that affects the salivary glands. The discovery could help physicians develop new treatments that target the cancer’s underlying genetic causes.
Dr. Antonio (Tony) Amelio begins his joint appointment as assistant professor in the UNC-Chapel Hill Adams School of Dentistry and Lineberger Comprehensive Cancer Center.
Antonio Amelio receives the Howard Temin Pathway to Independence Award in Cancer Research from the National Cancer Institute. The multiyear award is designed to accelerate the progress of promising junior scientists to scientific independence.
Antonio L. Amelio was presented a Scholar-in-Training Award by the American Association for Cancer Research (AACR). Sponsored by Aflac Inc. to recognize outstanding papers by early-career cancer research scientists .